Hydrochloric Acid → 5-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride

HRID 336362ノート

反応式

HRID 336362 の反応式
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>O1CCOCC1>[ClH:22].[CH3:21][O:20][C:17]1[CH:16]=[N:15][C:14]([N:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:19][CH:18]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 86686610HCID 86686610、化合物

生成物 1

HCID 866866095-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

953 mg 4-(5-methoxy-pyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester was stirred in 16 mL 4 mol/L HCl solution in dioxane for 45 min The precipitate was filtered, washed with dioxane and dried to yield 723 mg of the desired compound. Rt: 0.46 min (method F), (M+H)+: 195

後処理

  1. filtrationwas filtered
  2. washwashed with dioxane
  3. customdried

出典と根拠

ORDレコード
ord-7a6a80d248bd45a09b68584c19b3a29d
出典データセット
uspto-grants-2014_11
特許番号
US08889677B2

反応ノート

読み込み中…