HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 86686610 | HCID 86686610 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 5-Methoxy-2-piperazin-1-yl-pyrimidine hydrochloride | HCID 86686609 | — |
Reaction Steps
953 mg 4-(5-methoxy-pyrimidin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester was stirred in 16 mL 4 mol/L HCl solution in dioxane for 45 min The precipitate was filtered, washed with dioxane and dried to yield 723 mg of the desired compound. Rt: 0.46 min (method F), (M+H)+: 195
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889677B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-7a6a80d248bd45a09b68584c19b3a29d |
| Source note | uspto-grants-2014_11 |