Thionyl Chloride → 4-Bromo-3-methylbenzoyl chloride

HRID 336367Notes

Reaction equation

HRID 336367 reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[CH3:11].S(Cl)([Cl:14])=O>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:14])=[O:7])=[CH:4][C:3]=1[CH3:11]

Participants

3

Reactant 2

HCID 24386Thionyl Chloride

HCID 821314-Bromo-3-methylbenzoic acid

Product 1

HCID 70215344-Bromo-3-methylbenzoyl chlorideYield 101.3%

Procedure

1 g 4-bromo-3-methyl-benzoic acid in 20 g thionylchloride was refluxed 1 h. The reaction was evaporated to give 1.1 g desired product.

Workup

customThe reaction was evaporated

Sources & evidence

ORD record: ord-46323ba7c797469e8ef7cda78c5ef4b2
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889677B2

Reaction notes

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