Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Fluorobenzonitrile → 4-Fluorobenzamidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Fluorobenzonitrile | HCID 14517 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 4-Fluorobenzamidine | HCID 4295238 | — |
반응 단계
380 mL 1N LiHMDS-solution in n-hexane was added to 20 g 4-fluoro-benzonitrile in 1 L diethylether. The reaction was stirred 2 h at RT and 4N HCL solution was added at 0° C. until pH=12. The water layer was extracted with chloroform. The organic layer was dried and evaporated to give 6.64 g of the desired product. Rt: 2.28 min (method K), (M+H)+: 139
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08889677B2 |
| 출처 데이터셋 | uspto-grants-2014_11 |
| ORD ID | ord-86a9286ea88c4f02aaaf771257efd45d |
| 출처 메모 | uspto-grants-2014_11 |