反应详情

380 mL 1N LiHMDS-solution in n-hexane was added to 20 g 4-fluoro-benzonitrile in 1 L diethylether. The reaction was stirred 2 h at RT and 4N HCL solution was added at 0° C. until pH=12. The water layer was extracted with chloroform. The organic layer was dried and evaporated to give 6.64 g of the desired product. Rt: 2.28 min (method K), (M+H)+: 139

1. addition4N HCL solution was added at 0° C. until pH=12
2. extractionThe water layer was extracted with chloroform
3. customThe organic layer was dried
4. customevaporated