HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl bromoacetate | HCID 60984 | — |
| Reactant | 3,5-bis-(4-Fluoro-phenyl)-1H-(1,2,4)triazole | HCID 86686515 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester | HCID 86686516 | 91.1% |
Reaction Steps
26.5 g 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole, 62.6 g K2CO3 and 15.7 g 2-bromoacetic acid methyl ester were dissolved in 1 L acetone and stirred for 24 h under reflux. K2CO3 was filtered and the solvent was removed to yield 30.8 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889677B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-f98154b7f9b849e58d40b4c4c7d6ac00 |
| Source note | uspto-grants-2014_11 |