Potassium Carbonate → (3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl ester

HRID 336373Notes

Reaction equation

HRID 336373 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=3)[NH:10][N:9]=2)=[CH:4][CH:3]=1.C([O-])([O-])=O.[K+].[K+].[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[CH3:26][O:27][C:28](=[O:31])[CH2:29][N:9]1[C:8]([C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=2)=[N:12][C:11]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)=[N:10]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 866865153,5-bis-(4-Fluoro-phenyl)-1H-(1,2,4)triazole

Product 1

HCID 86686516(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetic acid methyl esterYield 91.1%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

26.5 g 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole, 62.6 g K2CO3 and 15.7 g 2-bromoacetic acid methyl ester were dissolved in 1 L acetone and stirred for 24 h under reflux. K2CO3 was filtered and the solvent was removed to yield 30.8 g of the desired product.

Workup

  1. temperatureunder reflux
  2. filtrationK2CO3 was filtered
  3. customthe solvent was removed

Sources & evidence

ORD record
ord-f98154b7f9b849e58d40b4c4c7d6ac00
Source dataset
uspto-grants-2014_11
Patent number
US08889677B2

Reaction notes

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