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HRID336373

反应详情

EQUATION

反应方程式

HRID 336373 的结构方程式

REACTANTS

反应物

3
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COC(=O)CBr
HCID60984

Methyl bromoacetate

C3H5BrO2

结构：Fc1ccc(-c2n[nH]c(-c3ccc(F)cc3)n2)cc1
HCID86686515

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)Cn1nc(-c2ccc(F)cc2)nc1-c1ccc(F)cc1
HCID86686516

未命名化合物

收率 91.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)=O
溶剂HCID180

Acetone

C3H6O

PROCEDURE

实验过程

26.5 g 3,5-bis-(4-fluoro-phenyl)-1H-(1,2,4)triazole, 62.6 g K2CO3 and 15.7 g 2-bromoacetic acid methyl ester were dissolved in 1 L acetone and stirred for 24 h under reflux. K2CO3 was filtered and the solvent was removed to yield 30.8 g of the desired product.

WORKUP

后处理

  1. temperatureunder reflux
  2. filtrationK2CO3 was filtered
  3. customthe solvent was removed