Triethylamine → 2-(4-(2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-pipera zin-1-yl)-nicotinonitrile

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	2-(Piperazin-1-yl)pyridine-3-carbonitrile	HCID 2737203	—
Reactant	(3,5-bis-(4-Fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride	HCID 86686520	—
Solvent	Dichloromethane	HCID 6344	—
Product	2-(4-(2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl)-pipera zin-1-yl)-nicotinonitrile	HCID 71667426	29.6%

Reaction Steps

126 mg 2-piperazin-1-yl-nicotinonitrile was added to 216 mg (3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-acetyl chloride and 150 μL triethylamine in 10 mL dichlormethane. The reaction was stirred 1 day at RT, the solvant was evaporated and the residue was purified by HPLC to give 93 mg of the desired product. (M+H)+: 486

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08889677B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-0071da91dd2d4ce4a0b89e7ce024dfd1
Source note	uspto-grants-2014_11