Ethylene Glycol → 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-(2-hydroxy-ethoxy)-pyrimidin-4-yl)-piperazin-1-yl)-ethanone

Participants

Role	Name	HCID	Charge
Reactant	Ethylene Glycol	HCID 174	—
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone	HCID 86690173	—
Solvent	Ethanol	HCID 702	—
Product	2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-(2-hydroxy-ethoxy)-pyrimidin-4-yl)-piperazin-1-yl)-ethanone	HCID 86690174	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

50 mg 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone and 3 mL ethane-1,2-diol were added to 10 mg potassiumcarbonate in 3 mL ethanol. The reaction was stirred 30 min at 150° C. under microwave conditions. The solvent was removed and the precipate was purified by HPLC to give 29 mg of the desired product. Rt: 1.87 min (method C), (M+H)+: 522

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08889677B2
Source dataset	uspto-grants-2014_11
ORD ID	ord-ce3a8b456d0c4ee0b2782d3a0b95cc3a
Source note	uspto-grants-2014_11