Diisopropylethylamine → HCID 86690175, compound

HRID 336386Notes

Reaction equation

[CH3:1][NH:2][CH2:3][CH:4]1[CH2:8][CH2:7][O:6][CH2:5]1.[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[N:18]([CH2:28][C:29]([N:31]3[CH2:36][CH2:35][N:34]([C:37]4[CH:42]=[C:41](Cl)[N:40]=[CH:39][N:38]=4)[CH2:33][CH2:32]3)=[O:30])[N:17]=2)=[CH:12][CH:11]=1.CCN(C(C)C)C(C)C>CS(C)=O>[F:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[N:18]([CH2:28][C:29]([N:31]3[CH2:36][CH2:35][N:34]([C:37]4[CH:42]=[C:41]([N:2]([CH3:1])[CH2:3][CH:4]5[CH2:8][CH2:7][O:6][CH2:5]5)[N:40]=[CH:39][N:38]=4)[CH2:33][CH2:32]3)=[O:30])[N:17]=2)=[CH:12][CH:11]=1

Participants

Conditions

Temperature: 80 °C

Procedure

58 mg methyl-(tetrahydro-furan-3-ylmethyl)-amine was added to 50 mg 2-(3,5-Bis-(4-fluoro-phenyl)-(1,2,4)triazol-1-yl)-1-(4-(6-chloro-pyrimidin-4-yl)-piperazin-1-yl)-ethanone and 35 μl DIPEA in 1 mL DMSO. The reaction was stirred 3 h at 80° C. The mixture was purified by HPLC to give 44 mg of the desired product. Rt: 2.13 min (method M), (M+H)+: 575

Workup

customThe mixture was purified by HPLC

Sources & evidence

ORD record: ord-ffbe3ef9979a4bb79d316677dda8c8f2
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889677B2

Reaction notes

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