関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Maleic Acid | HCID 444266 | — |
| 反応物 | Eszopiclone | HCID 969472 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 86633612 | HCID 86633612 | 76% |
反応手順
A reactor was charged with 0.101 g (S)-zopiclone and 0.040 g maleic acid. The mixture was charged with 18 g ethanol, and agitated. The slurry was heated to 60° C. and aged for 90 minutes. The slurry was cooled to 20° C. and aged for 60 minutes. The reaction was filtered, washed once with 0.5 g ethanol, dried in vacuo at approximately 50° C. for approximately 6 hr, and provided the titled compound in 76% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08889685B2 |
|---|
| 出典データセット | uspto-grants-2014_11 |
|---|
| ORD ID | ord-0e8edbadd5694c8bbb6637ad37f09fe7 |
|---|
| 出典メモ | uspto-grants-2014_11 |
|---|
