Pyrrolidine → HCID 44126115, compound

HRID 336491Notes

Reaction equation

[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21]O)[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:23]1[CH2:27][CH2:26][CH2:25][CH2:24]1>>[CH:1]1([NH:6][C:7]2[CH:8]=[CH:9][CH:10]=[C:11]3[C:15]=2[NH:14][C:13]([C:16]2[S:17][CH2:18][C@@H:19]([CH2:21][N:23]4[CH2:27][CH2:26][CH2:25][CH2:24]4)[N:20]=2)=[CH:12]3)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 25196143HCID 25196143, compound

Product 1

HCID 44126115HCID 44126115, compound

Procedure

[(R)-2-(7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-methanol prepared in Example 2 and pyrrolidine were reacted according to the same procedure as Example 156 to give the title compound.

Sources & evidence

ORD record: ord-871e65fe1838465897041b457a33213d
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889691B2

Reaction notes

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