Ethanesulfonyl chloride → (5-Chloro-2-{(R)-4-[2-(4-ethanesulfonyl-piperazin-1-yl)-ethyl]-4,5-dihydro-thiazol-2-yl}-1H-indol-7-yl)-cyclopentyl-amine

HRID 336495Notes

Reaction equation

HRID 336495 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[N:21]=1)=[CH:5]2.[CH2:30]([S:32](Cl)(=[O:34])=[O:33])[CH3:31]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:16][CH2:15][CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:17]1[S:18][CH2:19][C@@H:20]([CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][N:27]([S:32]([CH2:30][CH3:31])(=[O:34])=[O:33])[CH2:26][CH2:25]3)[N:21]=1)=[CH:5]2

Participants

3

Reactant 2

HCID 11667Ethanesulfonyl chlorideHCID 59543099{5-Chloro-2-[(R)-4-(2-piperazin-1-yl-ethyl)-4,5-dihydro-thiazol-2-yl]-1H-indol-7-yl}-cyclopentyl-amine

Product 1

HCID 59543045(5-Chloro-2-{(R)-4-[2-(4-ethanesulfonyl-piperazin-1-yl)-ethyl]-4,5-dihydro-thiazol-2-yl}-1H-indol-7-yl)-cyclopentyl-amine

Procedure

{5-Chloro-2-[(R)-4-(2-piperazin-1-yl-ethyl)-4,5-dihydro-thiazol-2-yl]-1H-indol-7-yl}-cyclopentyl-amine prepared in Example 160 and ethyl sulfonylchloride were reacted according to the same procedure as Step B of Preparation 29 to give the title compound.

Workup

  1. customaccording to the same procedure as Step B of Preparation 29

Sources & evidence

ORD record
ord-d170956bdef14aac913f265e3df58d7b
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

Loading…