Morpholine → HCID 68486291, compound

HRID 336504Notes

Reaction equation

HRID 336504 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:11]([O-])=O)[CH:10]=1)[NH:7][C:6]([C:14]1[O:15][CH2:16][C@@H:17]([CH2:19][C:20](O)=O)[N:18]=1)=[CH:5]2.[O:23]1[CH2:28][CH2:27][C:26](=O)[CH2:25][CH2:24]1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>>[CH3:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:26]3[CH2:27][CH2:28][O:23][CH2:24][CH2:25]3)[CH:10]=1)[NH:7][C:6]([C:14]1[O:15][CH2:16][C@@H:17]([CH2:19][CH2:20][N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[N:18]=1)=[CH:5]2

Participants

4

Reactant 3

HCID 8083MorpholineHCID 121599Tetrahydro-4H-pyran-4-oneHCID 68487021HCID 68487021, compound

Product 1

HCID 68486291HCID 68486291, compound

Procedure

2-[(R)-2-(5-methyl-7-nitro-1H-indol-2-yl)-4,5-dihydro-oxazol-4-yl]acetic acid prepared in Example 104, tetrahydropyran-4-one and morpholine were consecutively reacted according to the same procedures as Example 1, Step A of Preparation 29, and Example 156 to give the title compound.

Workup

  1. customaccording to the same procedures as Example 1, Step A of Preparation 29, and Example 156

Sources & evidence

ORD record
ord-b3b41f45db7346ec98b41e5cadcfd6f9
Source dataset
uspto-grants-2014_11
Patent number
US08889691B2

Reaction notes

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