HCID 178524534, compound → HCID 178516122, compound

HRID 336514Notes

Reaction equation

HRID 336514 reaction equation
[OH:1][C:2]1[N:10]=[C:9]([OH:11])[C:8]([F:12])=[CH:7][C:3]=1C(O)=O>O1CCOCC1>[OH:11][C:9]1[C:8]([F:12])=[CH:7][CH:3]=[C:2]([OH:1])[N:10]=1

Participants

3

Reactant 1

HCID 178524534HCID 178524534, compound

Product 1

HCID 178516122HCID 178516122, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

2,6-Dihydroxy-5-fluoronicotinic acid (2.25 g) was dissolved in dioxane (25 mL) and refluxed for 15 minutes. After being cooled, the solvent was evaporated to obtain Compound 4a (1.65 g). Yield: 99%1 H-NMR (DMSOd6, δPPM): 7.26 (1H, dd, J=7.7 Hz, J=11.0 Hz), 5.45 (1H, d, J=6.6 Hz)

Workup

  1. temperaturerefluxed for 15 minutes
  2. temperatureAfter being cooled
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-40a616a8e52d443581beadd67e6f338b
Source dataset
uspto-grants-2014_11
Patent number
US08889699B2

Reaction notes

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