HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Azide → tert-Butyl 2-azido-7-azaspiro[3.5]nonane-7-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | tert-Butyl 2-((methylsulfonyl)oxy)-7-azaspiro[3.5]nonane-7-carboxylate | HCID 22248489 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | tert-Butyl 2-azido-7-azaspiro[3.5]nonane-7-carboxylate | HCID 86660638 | — |
Reaction Steps
A solution of 5.90 g (18.47 mmol) of tert-butyl 2-methanesulfonyloxy-7-azaspiro[3.5]nonane-7-carboxylate (WO 2003/084 948) and 3.60 g (55.41 mmol) of sodium azide in 27 mL of N,N-dimethylformamide is refluxed for 12 hours under an inert atmosphere.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889702B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-19adc2477eeb4cbdabe7ce8a4da3e8b9 |
| Source note | uspto-grants-2014_11 |