反应详情

In a sealed tube, a solution of 0.130 g (0.28 mmol) of ethyl 5-[2-(6-fluoroquinolin-2-yl)-2-azaspiro[3.3]hept-6-ylcarbamoyloxymethyl]isoxazole-3-carboxylate, prepared in step 11.9., in 4.13 mL (28.01 mmol) of a solution (8M) of methylamine in ethanol, is stirred at room temperature for 5 hours. The mixture is evaporated to dryness. The residue obtained is crystallized from hot ether. The precipitate thus formed is filtered off and rinsed thoroughly with ether. After drying under vacuum at about 60° C., 0.05 g of pure product is obtained in the form of a white powder.

1. customThe mixture is evaporated to dryness
2. customThe residue obtained
3. customis crystallized from hot ether
4. customThe precipitate thus formed
5. filtrationis filtered off
6. washrinsed thoroughly with ether
7. customAfter drying under vacuum at about 60° C.