HCID 86603565, compound → Imidazo[1,2-a]pyrazin-2-amine

HRID 336619Notes

Reaction equation

HRID 336619 reaction equation
FC(F)(F)C([NH:5][C:6]1[N:7]=[C:8]2[CH:13]=[N:12][CH:11]=[CH:10][N:9]2[CH:14]=1)=O>N.CO>[N:7]1[C:6]([NH2:5])=[CH:14][N:9]2[CH:10]=[CH:11][N:12]=[CH:13][C:8]=12

Participants

4

Reactant 1

HCID 86603565HCID 86603565, compound

Product 1

HCID 69382803Imidazo[1,2-a]pyrazin-2-amine

Reagents, catalysts & solvents 2

HCID 222AmmoniaSolventHCID 887MethanolSolvent

Conditions

Temperature
68 °C

Procedure

2,2,2-Trifluoro-N-(imidazo[1,2-a]pyrazin-2-yl)acetamide (prepared as described in WO2004/058266A1, 520 mg) was dissolved in 7N NH3 in methanol (4.0 mL), and heated at 68° C. in a sealed tube for 6 hours. The reaction mixture was then cooled and concentrated to provide the title compound.

Workup

  1. temperatureThe reaction mixture was then cooled
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-b6c8f7493a284037beef35c78fe7cee8
Source dataset
uspto-grants-2014_11
Patent number
US08889675B2

Reaction notes

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