反应详情

To a solution of EXAMPLE 84B (3.4 g) in tetrahydrofuran (40 mL) was added NaBH4 (0.5 g). The mixture was stirred overnight. The solvent was evaporated and the residue was added to ethyl acetate (300 mL) and water (50 mL). The organic layer was washed with water and brine, dried over Na2SO4, and filtered. Evaporation of the solvent gave the crude title compound.

1. customThe solvent was evaporated
2. additionthe residue was added to ethyl acetate (300 mL) and water (50 mL)
3. washThe organic layer was washed with water and brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customEvaporation of the solvent