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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 336676Generated: October 30, 2026

4-Methoxybenzaldehyde → 5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-one

https://huagongshe.com/reaction/336676

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-MethoxybenzaldehydeHCID 31244—
Reactant2-Amino-4,6-dimethoxybenzamideHCID 20349016—
Reactant5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-oneHCID 136037998—
Product5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-oneHCID 13603796144%

Reaction Steps

5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 4-methoxy benzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 5,7-Dimethoxy-2-(4-methoxyphenyl)quinazolin-4(3H)-one (106 mg, 44%) was isolated as an off-white solid. Selected data: MS (m/z): 312.99; MP 276-277° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08889698B2
Source datasetuspto-grants-2014_11
ORD IDord-0edf93b9416f431e9f9c1e444f1e413c
Source noteuspto-grants-2014_11