HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Pyridinecarboxaldehyde → 5,7-Dimethoxy-2-(pyridin-4-yl)quinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Pyridinecarboxaldehyde | HCID 13389 | — |
| Reactant | 2-Amino-4,6-dimethoxybenzamide | HCID 20349016 | — |
| Reactant | 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one | HCID 136037998 | — |
| Product | 5,7-Dimethoxy-2-(pyridin-4-yl)quinazolin-4(3H)-one | HCID 136037962 | 63% |
Reaction Steps
5,7-Dimethoxy-2-(pyridin-4-yl)quinazolin-4(3H)-one was synthesized from 2-amino-4,6-dimethoxybenzamide and 4-pyridine carboxaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 5,7-Dimethoxy-2-(pyridin-4-yl)quinazolin-4(3H)-one (142 mg, 63%) was isolated as a pale brown solid and then converted to the corresponding hydrochloride (yellow solid). Selected data: MS (m/z): 284.06; MP 294-295° C. (hydrochloride).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889698B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-6bb2fdc6592f4424972eaa035f488988 |
| Source note | uspto-grants-2014_11 |