HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4,5-dimethoxybenzamide → 2-(4-(Bis(2-hydroxyethyl)amino)phenyl)-6,7-dimethoxyquinazolin-4(3H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4,5-dimethoxybenzamide | HCID 10867236 | — |
| Reactant | 4-(N,N-Bis(2-hydroxyethyl)amino)benzaldehyde | HCID 12824965 | — |
| Reactant | 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one | HCID 136037998 | — |
| Product | 2-(4-(Bis(2-hydroxyethyl)amino)phenyl)-6,7-dimethoxyquinazolin-4(3H)-one | HCID 136037964 | 24% |
Reaction Steps
2-(4-(Bis(2-hydroxyethyl)amino)phenyl)-6,7-dimethoxyquinazolin-4(3H)-one was synthesized from 2-amino-4,5-dimethoxy-benzamide and 4-(N,N-bis(2-hydroxyethyl)amino)benzaldehyde, using the method described for 5,7-dimethoxy-2-(pyridin-2-yl)quinazolin-4(3H)-one. 2-(4-(Bis(2-hydroxyethyl)amino)phenyl)-6,7-dimethoxyquinazolin-4(3H)-one (72 mg, 24%) was isolated as a yellow solid. Selected data: MS (m/z): 386.15; MP 268-270° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08889698B2 |
| Source dataset | uspto-grants-2014_11 |
| ORD ID | ord-24d64564efa7409698ec027ee972a298 |
| Source note | uspto-grants-2014_11 |