反应详情

To a solution of 0.20 g (1.1 mmol) of 5-(bromomethyl)furan-2-carboxaldehyde in anhydrous dioxane (10 ml) are added 261 μL (0.24 g, 2.3 mmol) of 1-methylpiperazine. The mixture is stirred at room temperature for 30 min. The precipitate formed is filtered and rinsed with dioxane. The filtrate is concentrated, dissolved in dichloromethane, and washed in water. The organic phase is dried over magnesium sulfate, filtered, and concentrated. The residue obtained is purified by chromatography on silica (eluent: 7N NH4OH in MeOH/CH2Cl2, 5:95) to yield 0.12 g (55%) of 5-((4-methylpiperazine-1-yl)methyl)furan-2-carboxaldehyde in the form of an orange solid.

1. customThe precipitate formed
2. filtrationis filtered
3. washrinsed with dioxane
4. concentrationThe filtrate is concentrated
5. dissolutiondissolved in dichloromethane
6. washwashed in water
7. dry with materialThe organic phase is dried over magnesium sulfate
8. filtrationfiltered
9. concentrationconcentrated
10. customThe residue obtained
11. customis purified by chromatography on silica (eluent: 7N NH4OH in MeOH/CH2Cl2, 5:95)