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HRID336935

反应详情

EQUATION

反应方程式

HRID 336935 的结构方程式

REACTANTS

反应物

3
结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：O=S(=O)(Cl)CCl
HCID77054

Methanesulfonyl chloride, chloro-

CH2Cl2O2S

结构：CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)NC(=O)N1c1cccc(C(F)(F)F)c1
HCID42642360

未命名化合物

PRODUCTS

生成物

1
结构：CC1=C(C#N)[C@@H](c2ccc(C#N)cc2S(C)(=O)=O)N(S(=O)(=O)CCl)C(=O)N1c1cccc(C(F)(F)F)c1
HCID66602134

未命名化合物

收率 69.2%

PROCEDURE

实验过程

Analogously to the preparation of Example 27, (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile (100 mg, 217 μmol; Example 6), sodium hydride (60%, 11.3 mg, 282 μmol) and chloromethanesulfonyl chloride (42 mg, 282 μmol) were reacted with one another for 3 h. This gave the title compound as a colorless solid (86 mg, 69% of theory).

WORKUP

后处理

  1. customwere reacted with one another for 3 h