反应详情

温度

100 °C

A solution of α,α-dimethyl-2-(phenylmethoxy)-benzenemethanamine (Example 198d, 1.5 g) dissolved in dioxane (52.2 mL) was treated with methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate (Example 1b, 2.499 g) and N-ethyldiisopropylamine (1.083 mL) under nitrogen. The resulting solution was stirred at 100° C. for 10 h. After cooling to room temperature, the reaction mixture was diluted with water (50 mL), and extracted with ethyl acetate (100 mL×2). The organic was dried (MgSO4), filtered and evaporated. The crude product was trituated with 50% diethyl ether in iso-hexane for 3 h. The solid was filtered off to afford the subtitle compound (2.405 g).

1. temperatureAfter cooling to room temperature
2. extractionextracted with ethyl acetate (100 mL×2)
3. dry with materialThe organic was dried (MgSO4)
4. filtrationfiltered
5. customevaporated
6. waitThe crude product was trituated with 50% diethyl ether in iso-hexane for 3 h
7. filtrationThe solid was filtered off