反应详情

温度

83 °C

A solution of N-cyclopropyl-3-fluoro-5-[3-[[1-(2-hydroxyphenyl)-1-methylethyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzamide (Example 252j, 7.08 g) dissolved in acetonitrile (150 mL) was treated with potassium carbonate (22.42 g) and 1-bromo-2-chloroethane (13.50 mL) under nitrogen. The resulting suspension was stirred at 83° C. for 10 h. The reaction mixture was evaporated to dryness, diluted with water (300 mL), and extracted with dichloromethane. The organic layer was dried (MgSO4) and evaporated. The crude product was triturated with 50% diethyl ether in iso-hexane to afford subtitle compound (7.58 g).

1. customThe reaction mixture was evaporated to dryness
2. additiondiluted with water (300 mL)
3. extractionextracted with dichloromethane
4. dry with materialThe organic layer was dried (MgSO4)
5. customevaporated
6. customThe crude product was triturated with 50% diethyl ether in iso-hexane