反应详情

温度

75 °C

To 3-[5-bromo-3-[[1-[5-fluoro-2-(phenylmethoxy)phenyl]cyclopropyl]amino]-2-oxo-1(2H)-pyrazinyl]-4-methyl-benzoic acid, methyl ester (Example 278b, 2.8 g) in ethanol (200 mL) was added ammonium formate (5.0 g) and 10% Pd/C (1.0 g). The reaction was heated at 75° C. for 1 h, filtered through celite washing the celite with warm ethanol (100 mL) followed by dichloromethane (2000 mL). The combined filtrates were evaporated, diluted with dichloromethane (1000 mL) and washed with water, dried (MgSO4) and evaporated to give the subtitle compound (1.2 g)

1. filtrationfiltered through celite
2. washwashing the celite with warm ethanol (100 mL)
3. customThe combined filtrates were evaporated
4. additiondiluted with dichloromethane (1000 mL)
5. washwashed with water
6. dry with materialdried (MgSO4)
7. customevaporated