Piperidine → HCID 66685835, compound

HRID 337166Notes

Reaction equation

[CH:1]1([NH:4][C:5](=[O:33])[C:6]2[CH:11]=[C:10]([N:12]3[CH:17]=[CH:16][N:15]=[C:14]([NH:18][C@@H:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C@@H:20]([CH3:23])[CH:21]=O)[C:13]3=[O:30])[C:9]([CH3:31])=[C:8]([F:32])[CH:7]=2)[CH2:3][CH2:2]1.[NH:34]1[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]1>>[CH:1]1([NH:4][C:5](=[O:33])[C:6]2[CH:11]=[C:10]([N:12]3[CH:17]=[CH:16][N:15]=[C:14]([NH:18][C@@H:19]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[C@@H:20]([CH3:23])[CH2:21][N:34]4[CH2:39][CH2:38][CH2:37][CH2:36][CH2:35]4)[C:13]3=[O:30])[C:9]([CH3:31])=[C:8]([F:32])[CH:7]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 8082Piperidine

HCID 86663259HCID 86663259, compound

Product 1

HCID 66685835HCID 66685835, compound

Procedure

The title compound was prepared from N-cyclopropyl-3-fluoro-4-methyl-5-[3-{[(1R,2R)-2-methyl-3-oxo-1-phenylpropyl]amino}-2-oxopyrazin-1(2H)-yl]benzamide (Example 328e) and piperidine using a similar method to that described for Example 328f.

Sources & evidence

ORD record: ord-2853aea3dcb74bb48fdb29f4f2110a57
Source dataset: uspto-grants-2014_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08889692B2

Reaction notes

Loading…