反应详情

To a solution of Ethyl 3-(2,6-dimethylbenzyloxy)-4-methoxybenzoate (Step B, 6.04 g, 19.23 mmol) in dry THF (30 ml) was added drop wise LiAlH4 (1M in THF, 0.803 g, 21.16 mmol) at 0° C. under argon. The reaction mixture was stirred for 4 hours or until all the starting material is consumed, then quenched slowly with 0.1N HCl, EtOAc (20 ml) was added to the reaction mixture. The reaction mixture was filtered and precipitate was washed with EtOAc (25 ml×2). The combined organic layer was washed with 0.1N HCl, brine, dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 4:1) to give the title compound.

1. customis consumed
2. customquenched slowly with 0.1N HCl, EtOAc (20 ml)
3. additionwas added to the reaction mixture
4. filtrationThe reaction mixture was filtered
5. washprecipitate was washed with EtOAc (25 ml×2)
6. washThe combined organic layer was washed with 0.1N HCl, brine
7. dry with materialdried over Na2SO4
8. filtrationfiltered
9. concentrationconcentrated
10. custompurified by flash chromatography on a silica gel column (hex: ethyl acetate 4:1)