反应详情

To a solution of 3-(2,6-Dimethylbenzyloxy)-2-methoxybenzaldehyde (Step B, 10.6 g, 32.7 mmol) in dry THF (40 ml) was added drop wise LiAlH4 (1M in THF, 0.95 g, 23.7 mmol) at 0° C. under argon. The reaction mixture was stirred for 1 hours or until all the starting material is consumed, then quenched by adding water slowly, followed by addition of 1N HCl (5 ml), water (10 ml), and EtOAc (20 ml) was added to the reaction mixture. The reaction mixture was concentrated, and passed through a short silica gel column using ethyl acetate to give the title compound as an off white solid.

1. customis consumed
2. customquenched
3. additionby adding water slowly
4. additionfollowed by addition of 1N HCl (5 ml), water (10 ml), and EtOAc (20 ml)
5. additionwas added to the reaction mixture
6. concentrationThe reaction mixture was concentrated