Hydrochloric Acid → HCID 60143704, compound

HRID 337334Notes

Reaction equation

HRID 337334 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH3:13])=[C:11]([CH2:14][CH2:15][C:16]([O:18]C)=[O:17])[C:10]([CH3:20])=[N:9]1.[OH-].[Na+].O.Cl>CO>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[C:12]([CH3:13])=[C:11]([CH2:14][CH2:15][C:16]([OH:18])=[O:17])[C:10]([CH3:20])=[N:9]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 60143552HCID 60143552, compound

Product 1

HCID 60143704HCID 60143704, compoundYield 26.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

29.9 mg of methyl 3-(1-(2-hydroxyphenyl)-3,5-dimethyl-1Hpyrazol-4-yl)propanoate was dissolved in 0.6 ml of methanol, and to the mixture was added 0.29 ml of 1N-sodium hydroxide and stirred at room temperature for 3.5 hours. To the reaction mixture was added 20 ml of water, neutralized with 1N-hydrochloric acid, and extracted with 20 ml of ethyl acetate. After the organic layer was dried over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to yield 7.5 mg of the title compound.

Workup

  1. extractionextracted with 20 ml of ethyl acetate
  2. dry with materialAfter the organic layer was dried over anhydrous magnesium sulfate
  3. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-04e2821d0727472592cbb38b32b4bf27
Source dataset
uspto-grants-2014_11
Patent number
US08889727B2

Reaction notes

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