HCID 60143703, compound → HCID 60143706, compound

HRID 337335Notes

Reaction equation

HRID 337335 reaction equation
[CH3:1][C:2]1[CH:6]=[C:5]([CH3:7])[N:4]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][C:9]=2[OH:17])[N:3]=1>C(O)C.[Pd]>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([N:4]2[C:5]([CH3:7])=[CH:6][C:2]([CH3:1])=[N:3]2)=[C:9]([OH:17])[CH:10]=1

Participants

4

Reactant 1

HCID 60143703HCID 60143703, compound

Product 1

HCID 60143706HCID 60143706, compoundYield 40.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

86 mg of 2-(3,5-dimethyl-1H-pyrazol-1-yl)-5-nitrophenol was dissolved in 1.7 ml of ethanol, and 43 mg of 10% palladium/carbon was added and stirred under hydrogen atmosphere at room temperature for 45 minutes. After the insoluble matter was filtered off, the solvent was distilled off under reduced pressure to yield 30.4 mg of the title compound.

Workup

  1. filtrationAfter the insoluble matter was filtered off
  2. distillationthe solvent was distilled off under reduced pressure

Sources & evidence

ORD record
ord-4aa6c05bcf6a49d8a81f22ed3d8ec902
Source dataset
uspto-grants-2014_11
Patent number
US08889727B2

Reaction notes

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