(2,3-dihydro-1H-inden-5-yl)boronic acid → 5-(2,3-dihydro-1H-inden-5-yl)-4-methoxythiophene-3-carbonitrile

HRID 337372Notes

Reaction equation

HRID 337372 reaction equation
[CH3:1][O:2][C:3]1[C:4]([C:18]#[N:19])=[CH:5][S:6][C:7]=1[C:8]1[CH:17]=[CH:16][C:15]2[CH2:14][CH2:13][CH2:12]C[C:10]=2[CH:9]=1.C1C2C(=CC(B(O)O)=CC=2)CC1>>[CH2:14]1[C:15]2[C:16](=[CH:17][C:8]([C:7]3[S:6][CH:5]=[C:4]([C:18]#[N:19])[C:3]=3[O:2][CH3:1])=[CH:9][CH:10]=2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 22240187(2,3-dihydro-1H-inden-5-yl)boronic acidHCID 681614114-Methoxy-5-(5,6,7,8-tetrahydronaphthalen-2-yl)thiophene-3-carbonitrile

Product 1

HCID 681606365-(2,3-dihydro-1H-inden-5-yl)-4-methoxythiophene-3-carbonitrileYield 85.6%

Procedure

Synthesis was carried out in the same manner as in Synthesis Method 2 (4) in Reference Synthetic Example 3 by using 4.08 g (0.0252 mol) of (2,3-dihydro-1H-inden-5-yl)boronic acid described in Reference Synthetic Example 5(1) to obtain 5.0 g of the desired product (yield: 85.6%).

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-40fbbe33aaef4172b2bf3f84150e2ebd
Source dataset
uspto-grants-2014_11
Patent number
US08889732B2

Reaction notes

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