1-[4-Hydroxy-5-(5,6,7,8-tetrahydronaphthalen-2-yl)thiophen-3-yl]ethanone → 1-[5-(2,3-dihydro-1H-inden-5-yl)-4-hydroxythiophen-3-yl]ethanone

HRID 337374Notes

Reaction equation

HRID 337374 reaction equation
[OH:1][C:2]1[C:3]([C:17](=[O:19])[CH3:18])=[CH:4][S:5][C:6]=1[C:7]1[CH:16]=[CH:15][C:14]2[CH2:13][CH2:12][CH2:11]C[C:9]=2[CH:8]=1.C1C2C(=CC(C3SC=C(C(=O)C)C=3OC)=CC=2)CC1>>[CH2:13]1[C:14]2[C:9](=[CH:8][C:7]([C:6]3[S:5][CH:4]=[C:3]([C:17](=[O:19])[CH3:18])[C:2]=3[OH:1])=[CH:16][CH:15]=2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 681616421-[4-Hydroxy-5-(5,6,7,8-tetrahydronaphthalen-2-yl)thiophen-3-yl]ethanoneHCID 681620131-[5-(2,3-dihydro-1H-inden-5-yl)-4-methoxythiophen-3-yl]ethanone

Product 1

HCID 681612091-[5-(2,3-dihydro-1H-inden-5-yl)-4-hydroxythiophen-3-yl]ethanoneYield 37.3%

Procedure

Synthesis was carried out in the same manner as in Synthesis Method 2 (6) in Reference Synthetic Example 3 by using 3.5 g (0.0129 mol) of 1-[5-(2,3-dihydro-1H-inden-5-yl)-4-methoxythiophen-3-yl]ethanone to obtain 1.24 g of the desired product (yield: 37.3%).

Workup

  1. customSynthesis

Sources & evidence

ORD record
ord-4a09f03689a3430f9797742a565dbaf2
Source dataset
uspto-grants-2014_11
Patent number
US08889732B2

Reaction notes

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