Hydrazine hydrate (1:1) → HCID 178514418, compound

HRID 337379Notes

Reaction equation

HRID 337379 reaction equation
[NH:1]1[C:5]([C:6]2[CH:14]=[CH:13][C:9]([C:10]([O-])=[O:11])=[CH:8][CH:7]=2)=[N:4][N:3]=[N:2]1.O.[NH2:16][NH2:17]>C(O)C>[NH:1]1[C:5]([C:6]2[CH:14]=[CH:13][C:9]([C:10]([NH:16][NH2:17])=[O:11])=[CH:8][CH:7]=2)=[N:4][N:3]=[N:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 178524269HCID 178524269, compound

Product 1

HCID 178514418HCID 178514418, compoundYield 47.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.20 g (0.99 mmol) of the 4-(1H-tetrazol-5-yl)benzoate was heated with ethanol (3.2 ml) and 0.84 g (16.8 mmol) of hydrazine monohydrate under reflux for 8.5 hours, and then the reaction solution was cooled to room temperature, and the precipitated pale yellow solid was collected by filtration through a Kiriyama funnel, washed with methanol and dried under reduced pressure to obtain the desired product (0.096 g, yield 47%, purity 99%).

Workup

  1. temperatureunder reflux for 8.5 hours
  2. filtrationthe precipitated pale yellow solid was collected by filtration through a Kiriyama funnel
  3. washwashed with methanol
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-7168ae300e954100a6e9d070600e2b37
Source dataset
uspto-grants-2014_11
Patent number
US08889732B2

Reaction notes

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