反应详情

0.20 g (0.99 mmol) of the 4-(1H-tetrazol-5-yl)benzoate was heated with ethanol (3.2 ml) and 0.84 g (16.8 mmol) of hydrazine monohydrate under reflux for 8.5 hours, and then the reaction solution was cooled to room temperature, and the precipitated pale yellow solid was collected by filtration through a Kiriyama funnel, washed with methanol and dried under reduced pressure to obtain the desired product (0.096 g, yield 47%, purity 99%).

1. temperatureunder reflux for 8.5 hours
2. filtrationthe precipitated pale yellow solid was collected by filtration through a Kiriyama funnel
3. washwashed with methanol
4. customdried under reduced pressure