Hydrazine hydrate (1:1) → 5-(hydrazinecarbonyl)-N-[4-(2-hydroxyethylcarbamoyl)benzyl]thiophene-2-carboxamide

Participants

Reaction Steps

0.73 g (2.02 mmol) of methyl 5-[-(2-hydroxyethylcarbamoyl)benzylcarbamoyl]thiophene-2-carboxylate in 12 mL of ethanol was mixed with 1.67 mL (34.43 mmol) of hydrazine monohydrate and heated under reflux for 9 hours. The reaction solution was cooled with ice, and the precipitated solid was collected by filtration, washed with ethanol and dried under reduced pressure to obtain the desired product (0.68 g, yield 93%).

Provenance & Evidence