反应详情

0.73 g (2.02 mmol) of methyl 5-[-(2-hydroxyethylcarbamoyl)benzylcarbamoyl]thiophene-2-carboxylate in 12 mL of ethanol was mixed with 1.67 mL (34.43 mmol) of hydrazine monohydrate and heated under reflux for 9 hours. The reaction solution was cooled with ice, and the precipitated solid was collected by filtration, washed with ethanol and dried under reduced pressure to obtain the desired product (0.68 g, yield 93%).

1. temperatureheated
2. temperatureunder reflux for 9 hours
3. temperatureThe reaction solution was cooled with ice
4. filtrationthe precipitated solid was collected by filtration
5. washwashed with ethanol
6. customdried under reduced pressure