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HRID33742

反应详情

EQUATION

反应方程式

HRID 33742 的结构方程式

REACTANTS

反应物

2
结构：O=C(c1ncc[nH]1)c1ncc[nH]1
HCID5250894

未命名化合物

结构：O=C1c2ccccc2C(=O)N1C[C@H](O)CNc1ccc(N2CCOCC2)c(F)c1
HCID16655949

2-{(2R)-3-[3-Fluoro-4-(morpholin-4-yl)anilino]-2-hydroxypropyl}-1H-isoindole-1,3(2H)-dione

C21H22FN3O4

PRODUCTS

生成物

1
结构：O=C1c2ccccc2C(=O)N1C[C@H]1CN(c2ccc(N3CCOCC3)c(F)c2)C(=O)O1
HCID12973056

2-({(5S)-3-[3-Fluoro-4-(morpholin-4-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

C22H20FN3O5

收率 79.1%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl)aniline (57 gm) is dissolved in methylene dichloride (600 ml), carbonyl diimidazole (32 gm) is added at ambient temperature and the reaction mixture is stirred for 20 hours. The reaction mass is washed with water and methylene dichloride is distilled to give 48 gm of (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide as solid.

WORKUP

后处理

  1. washThe reaction mass is washed with water and methylene dichloride
  2. distillationis distilled