HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Bis-(1H-imidazol-2-YL)-methanone → N-((3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)phthalimide, (S)-
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| Edukt | (R)-2-(3-((3-Fluoro-4-morpholinophenyl)amino)-2-hydroxypropyl)isoindoline-1,3-dione | HCID 16655949 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | N-((3-(3-Fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)phthalimide, (S)- | HCID 12973056 | 79,1% |
Reaktionsschritte
N-[3-pthalimido-2-(R)-hydroxypropyl]-3-fluoro-4-(morpholinyl)aniline (57 gm) is dissolved in methylene dichloride (600 ml), carbonyl diimidazole (32 gm) is added at ambient temperature and the reaction mixture is stirred for 20 hours. The reaction mass is washed with water and methylene dichloride is distilled to give 48 gm of (S)-N-[[3-[3-Fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]phthalimide as solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07429661B2 |
| Quelldatensatz | uspto-grants-2008_09 |
| ORD ID | ord-2b95dc978d5f42ef9304f078b3507e96 |
| Quellennotiz | uspto-grants-2008_09 |