反应详情

Compound 135 (6.18 g, 16.7 mmol) was dissolved in trifluoroacetic acid (17 mL), followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure, ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate were added to the residue, and the organic layer was separated. The organic layer was washed with a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate, and then the solvent was distilled away under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane:ethyl acetate=1:4) to afford the entitled Compound 136 (4.39 g, 97%).

1. concentrationThe reaction mixture was concentrated under reduced pressure, ethyl acetate
2. additiona saturated aqueous solution of sodium hydrogencarbonate were added to the residue
3. customthe organic layer was separated
4. washThe organic layer was washed with a saturated aqueous solution of sodium chloride
5. dry with materialdried over anhydrous magnesium sulfate
6. distillationthe solvent was distilled away under reduced pressure
7. customThe resulting residue was purified through silica gel column chromatography (hexane:ethyl acetate=1:4)