Hydrogen Bromide → HCID 86612466, compound

HRID 337469Notes

Reaction equation

HRID 337469 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[S:15][C:14]([NH2:16])=[N:13][C:12]=2[C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)=[O:10])=[CH:5][N:4]=1.Br.C(=O)([O-])[O-].[Na+].[Na+]>C(O)(=O)C>[O:2]=[C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:11]2[S:15][C:14]([NH2:16])=[N:13][C:12]=2[C:17]2[O:18][CH:19]=[CH:20][CH:21]=2)=[O:10])=[CH:5][NH:4]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 10340Sodium CarbonateHCID 23144243HCID 23144243, compound

Product 1

HCID 86612466HCID 86612466, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

Compound 318 (1.36 g, 4.51 mmol) was dissolved in acetic acid (4 mL), and 48% hydrobromic acid (4 mL) was added thereto, followed by stirring at 100° C. for 1 hour. The reaction mixture was poured into aqueous saturated sodium carbonate solution, and the precipitated solid was collected by filtration to afford the entitled Compound 358 (1.20 g, 93%).

Workup

  1. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-be5255866dd3443b839f1745172a4eb5
Source dataset
uspto-grants-2014_11
Patent number
US08889718B2

Reaction notes

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