Hexane → HCID 23144358, compound

HRID 337545Notes

Reaction equation

HRID 337545 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[S:13][C:12]([NH2:14])=[N:11][C:10]=1[C:15]1[O:16][CH:17]=[CH:18][CH:19]=1)=[O:8].[C:20](N1C=CN=C1)(N1C=CN=C1)=[O:21].CCCCCC>ClCCl>[O:16]1[CH:17]=[CH:18][CH:19]=[C:15]1[C:10]1[N:11]=[C:12]([N:14]=[C:20]=[O:21])[S:13][C:9]=1[C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:8]

Participants

5

Reactant 3

HCID 8058HexaneHCID 682631,1'-CarbonyldiimidazoleHCID 23144251HCID 23144251, compound

Product 1

HCID 23144358HCID 23144358, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 186 (200 mg, 0.737 mmol) was suspended in dichloromethane (15 mL), and carbonyldiimidazole (179 mg, 1.11 mmol) was added thereto at room temperature, followed by stirring at room temperature for 2 hours. Hexane (7.5 mL) was added to the reaction mixture, and the precipitated solid was collected by filtration to afford the entitled Compound y (133 mg, 61%) as a brown solid.

Workup

  1. customat room temperature
  2. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-d092cae179774c30b5e3646f6315f6b7
Source dataset
uspto-grants-2014_11
Patent number
US08889718B2

Reaction notes

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