反应详情

To a TFA solution (0.38 M) of 2,3-dichlorobenzaldehyde (1 eq.) was added sulfuric acid (5 eq.). Over a period of 3 h, N-bromosuccinimide (1.5 eq.) was added portionwise at RT to afford, in the end, a yellow-orange solution. After 72 h, the crude reaction mixture was diluted with 9:1 (v/v) hexanes:ether and then washed sequentially with water, 1 N aq. NaOH, water and brine. The organic extract was dried over Na2SO4, filtered and the filtrate concentrated in vacuo to afford the title compound as a white solid.

1. customto afford, in the end
2. waitAfter 72 h
3. customthe crude reaction mixture
4. washether and then washed sequentially with water, 1 N aq. NaOH, water and brine
5. extractionThe organic extract
6. dry with materialwas dried over Na2SO4
7. filtrationfiltered
8. concentrationthe filtrate concentrated in vacuo