反应详情

To a dichloromethane solution of 5-[3-(methyloxy)propyl]-2-(methylthio)benzyl alcohol (1 eq.) from the previous step was added sodium bicarbonate (5 eq.) and DMP (1.1 eq.). The resulting reaction suspension was stirred for 1.5 h at RT. The reaction was quenched with sat. aq. NaHSO3 and then extracted with dichloromethane. The combined organic extracts were washed further with 1 N aq. NaOH, water and brine, dried over MgSO4 and filtered. Concentration of the filtrate in vacuo afforded the crude title compound as a colorless oil.

1. customThe resulting reaction suspension
2. customThe reaction was quenched with sat. aq. NaHSO3
3. extractionextracted with dichloromethane
4. washThe combined organic extracts were washed further with 1 N aq. NaOH, water and brine
5. dry with materialdried over MgSO4
6. filtrationfiltered