反应详情

To a solution of 3-bromo-5-iodobenzoic acid (1.0 eq.) in THF (0.2 M) at RT was added borane-methyl sulfide complex (1.5 eq). After 3 days of stirring at RT, the reaction mixture was quenched cautiously with 2 N aq. HCl and extracted with ether. The combined organic extracts were washed with 1 N aq. NaOH, water and brine, dried over MgSO4 and filtered. Concentration of the filtrate in vacuo afforded the title compound as a colorless oil.

1. customthe reaction mixture was quenched cautiously with 2 N aq. HCl
2. extractionextracted with ether
3. washThe combined organic extracts were washed with 1 N aq. NaOH, water and brine
4. dry with materialdried over MgSO4
5. filtrationfiltered