Sodium ethoxide → HCID 131732021, compound

HRID 337671Notes

Reaction equation

HRID 337671 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C@H:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][C@H:10]2[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]=[CH:5][N:4]=1.[O-]CC.[Na+]>C(O)C>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C@@H:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:19])[CH3:20])=[O:16])[CH2:11][C@H:10]2[C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 131732020HCID 131732020, compound

Product 1

HCID 131732021HCID 131732021, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
55 °C

Procedure

To an ethanol solution (0.1 M) of cis-1-(1,1-dimethylethyl) 3-ethyl 4-[2-(methyloxy)-4-pyridinyl]-1,3-piperidinedicarboxylate (1 eq.) from the previous step was added freshly prepared sodium ethoxide (1.1 eq.). The resulting yellow-orange solution was heated at 55° C. for 12 h. The volatiles were then removed in vacuo and the residue was partitioned between diethyl ether and sat. aq. NH4Cl. The aqueous layer was separated and back-extracted with ether. The combined organic extracts were washed further with water and brine, dried over Na2SO4, filtered and the filtrate concentrated in vacuo. Purification of the crude product thus obtained by way of column chromatography (SiO2, 90:10 (v/v) Hex:EtOAc→EtOAc) afforded the title compound as a colorless oil.

Workup

  1. customThe volatiles were then removed in vacuo
  2. customthe residue was partitioned between diethyl ether and sat. aq. NH4Cl
  3. customThe aqueous layer was separated
  4. extractionback-extracted with ether
  5. washThe combined organic extracts were washed further with water and brine
  6. dry with materialdried over Na2SO4
  7. filtrationfiltered
  8. concentrationthe filtrate concentrated in vacuo
  9. customPurification of the crude product
  10. customthus obtained by way of column chromatography (SiO2, 90:10 (v/v) Hex:EtOAc→EtOAc)

Sources & evidence

ORD record
ord-14cb07de83c145159bba16c775027cce
Source dataset
uspto-grants-2014_11
Patent number
US08889714B2

Reaction notes

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