反应详情

To a solution of N-(2,4-dimethoxybenzyl)-2,4,5-trifluoro-N-(1,2,4-thiadiazol-5-yl)benzenesulfonamide (WO 2010/079443; 600 mg, 1.35 mmol) and (1S*,2R*)-2-phenylcyclohexanol (240 mg, 1.36 mmol) in DMSO (6.0 mL), sodium hydride (63%; 100 mg, 2.63 mmol) was added with cooling on ice, and the reaction solution was stirred at room temperature for 1 hour. Water (100 mL) was added to the reaction solution, followed by extraction with ethyl acetate (50 mL). The thus obtained organic layer was washed twice with water (200 mL) and dried over anhydrous sodium sulfate. After vacuum concentration, the residue was purified with silica gel chromatography (hexane/ethyl acetate=4:1) to yield the title compound (270 mg, 33%) as a colorless oil.

1. temperaturewith cooling on ice
2. extractionfollowed by extraction with ethyl acetate (50 mL)
3. washThe thus obtained organic layer was washed twice with water (200 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationAfter vacuum concentration
6. customthe residue was purified with silica gel chromatography (hexane/ethyl acetate=4:1)