Trifluoroacetic acid → HCID 89962780, compound

HRID 337712Notes

Reaction equation

HRID 337712 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([O:8][C@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]2[C:15]2[N:19]([CH3:20])[N:18]=[CH:17][CH:16]=2)[C:5]([F:21])=[CH:4][C:3]=1[S:22]([N:25]([C:33]1[N:34]=[CH:35][S:36][CH:37]=1)C(=O)OC(C)(C)C)(=[O:24])=[O:23].FC(F)(F)C(O)=O>ClCCl>[F:1][C:2]1[CH:7]=[C:6]([O:8][C@H:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]2[C:15]2[N:19]([CH3:20])[N:18]=[CH:17][CH:16]=2)[C:5]([F:21])=[CH:4][C:3]=1[S:22]([NH:25][C:33]1[N:34]=[CH:35][S:36][CH:37]=1)(=[O:23])=[O:24]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 131732049HCID 131732049, compound

Product 1

HCID 89962780HCID 89962780, compoundYield 179.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 1b by using the tert-butyl [(2,5-difluoro-4-{[(1S*,2R*)-2-(1-methyl-1H-pyrazol-5-yl)cyclohexyl]oxy}phenyl)sulfonyl](1,3-thiazol-4-yl)carbamate (177 mg, 0.319 mmol) prepared in Example 5a, trifluoroacetic acid (1.0 mL) and dichloromethane (1.0 mL), to yield the title compound (260 mg, 87%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-c878dd471bcc47dfa529f8497bfa9ea8
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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