Dichloromethane → HCID 178526906, compound

HRID 337914Notes

Reaction equation

HRID 337914 reaction equation
C(OC(=O)[N:7]([S:13]([C:16]1[C:21]([F:22])=[CH:20][C:19]([O:23][C@H:24]2[CH2:29][CH2:28][CH2:27][CH2:26][C@@H:25]2[C:30]2[C:31]([N+:41]([O-:43])=[O:42])=[N:32][N:33](C3CCCCO3)[CH:34]=2)=[CH:18][C:17]=1[F:44])(=[O:15])=[O:14])[C:8]1[N:9]=[CH:10][S:11][CH:12]=1)(C)(C)C.FC(F)(F)C(O)=O.ClCCl>CO>[F:22][C:21]1[CH:20]=[C:19]([O:23][C@H:24]2[CH2:29][CH2:28][CH2:27][CH2:26][C@@H:25]2[C:30]2[C:31]([N+:41]([O-:43])=[O:42])=[N:32][NH:33][CH:34]=2)[CH:18]=[C:17]([F:44])[C:16]=1[S:13]([NH:7][C:8]1[N:9]=[CH:10][S:11][CH:12]=1)(=[O:15])=[O:14]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 89963676HCID 89963676, compound

Product 1

HCID 178526906HCID 178526906, compoundYield 54.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 22c by using the tert-butyl{[2,6-difluoro-4-({(1S*,2R*)-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]cyclohexyl}oxy)phenyl]sulfonyl}1,3-thiazol-4-ylcarbamate (426 mg, 0.636 mmol) prepared in Example 116b, trifluoroacetic acid (1.0 mL), dichloromethane (1.0 mL) and methanol (0.1 mL), to yield the title compound (167 mg, 54%) as a colorless solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-82ef4d3130cf45cc83ad3e51c053043d
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

Loading…