4-Iodopyrazole → HCID 89962750, compound

HRID 337960Notes

Reaction equation

HRID 337960 reaction equation
I[C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([Li])CCC.[F:12][C:13]1([F:20])[CH2:18][CH2:17][C:16](=[O:19])[CH2:15][CH2:14]1>C1COCC1>[F:12][C:13]1([F:20])[CH2:18][CH2:17][C:16]([C:2]2[CH:3]=[N:4][NH:5][CH:6]=2)([OH:19])[CH2:15][CH2:14]1

Participants

5

Reactant 3

HCID 770224-IodopyrazoleHCID 157890924,4-DifluorocyclohexanoneHCID 178418339Butyllithium

Product 1

HCID 89962750HCID 89962750, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The reaction and aftertreatment were conducted in the same manner as in Example 8a by using 4-iodo-1H-pyrazole (5.82 g, 30.0 mmol), butyl lithium (2.69 M solution in hexane; 22.3 mL, 60.0 mmol), 4,4-difluorocyclohexanone (4.43 g, 33.0 mmol) and THF (120 mL), to yield the title compound (2.32 g, 55%) as a pale yellow solid.

Workup

  1. customThe reaction and aftertreatment

Sources & evidence

ORD record
ord-e71d6ad7828b41008c3a15852ba64f54
Source dataset
uspto-grants-2014_11
Patent number
US08889741B2

Reaction notes

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